A bus driver and a passenger were taken to hospital after the single-decker bus hit scaffolding in Coventry.
The driver, in his 40s, and a 19-year-old woman were hurt on Tuesday morning. Emergency crews made the area in Far Gosford Street safe.
National Express Coventry said a bus on the number 10 service was involved, and it was supporting any investigations into the crash.
The driver had minor injuries and the woman sustained an injury to her arm.
The ambulance service, which was called at about 0930 GMT, added that the two people were treated at the scene and taken to University Hospital Coventry.
The fire service said scaffolding contractors and the city council had attended the site, an area was cordoned off and a recovery vehicle had gone to the scene.
The scaffolding had been put around a grade II-listed building.
Two fire engines, from Coventry and Binley fire stations, were sent.